Welcome! This post will assess the claims and research regarding the efficacy of SeneGence’s LipVolumizer and explain its mechanism of action on a chemical level toward the potential development of a powerful pout.

Is it temporary or long-term? Is it irritating my skin? Learn more below!

Nix the “if it burns, it’s working” mantra…

PSA: There is a mouthwash you can purchase that doesn’t challenge your mental stamina for endured suffering. This concept of burning in evidence of working is often unnecessary and in the case of LipVolumizers, should not be normalized as (best-case scenario) the product is simply irritating your lips with an inflammatory agent to promote swelling via vasodilation and gives an unnatural, bee-sting appearance.

Worst-case scenario, these products are prone to allergic reactions particularly upon repeated exposure even when containing natural ingredients like cinnamon and peppermint (assuming this comprises the majority of the formulation). Another danger involves vasodilation, particularly if you suffer from an blood pressure related ailments or endure frequent vertigo. To be fair, however, this particular scenario is fairly unlikely as it involves the inflammation of an exterior portion of the body with topical application.

If you’re concerned about the burning of your lip plumper, refrain from use immediately and seek the guidance of a licensed medical professional (or just use SeneGence’s because ours does not burn or function under this mechanism). Read more below!

Okay, off the soap box and onto the science!

SeneDerm Solutions LipVolumizer™

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An Inward Approach to Outward Lip Plumping (without the needle)

If you’re searching for long-lasting lip volumizers/plumpers, you want to look for ingredients that engage in hydration and a term known as “cell boosting”. Basically these boosts provide a rich quantity of biological additives that promote healthy, regulated cellular growth for long-term development of the area on which they are applied.

These ingredients are: tripeptides, triglycerides, collagen, hyaluronic acid, and other biologics derived from living organisms.

Vegans be warned! If you’re specifically attuned to the avoidance of animal products, ensure your product derives their biological from algae, plant-life, or cultured bacteria (think yogurt not infectious little germ bots).

Avoid caffeinated products as these can damage your skin long-term by depleting their natural resources and embed in the dermis.

An Informative Breakdown of SeneGence’s LipVolumizer Ingredients

Ricinus Communis (Castor) Seed Oil

A natural remedy for constipation (if consumed) is castor oil. This potent de-pooper is packed with nourishing fatty acids (particularly ricinoleic acid, a monounsaturated, 18-carbon fatty acid) and can act as a natural cell growth promoter.

Castor oil as derived from Castor Beans

This oil has a high viscosity (its thick and pours slowly) owed to the intermolecular forces driving its ability to serve as an exceptional humectant and its deliverance of slow, deliberate quantities of nutrients.



Tripeptides, Hyaluronic Acid, and Sodium Hyaluronate

We mentioned these ingredients in the introduction of our post as one’s to look for in your quest for healthy, long-lasting lip volumizers.

An overview of the aging process…

As we age, our DNA has a harder and harder time protecting its telomeres (the ends of our genetic code) from damage and cleavage. As a result, our body needs to prioritize which types of proteins it most needs to code (survival, health, lungs, brain, etc.) as opposed to in our youth where vitality and reproductive health were equally important for the proliferation of the human race (thus youthful skin, hips, breast, lips, hair, etc.).


However, we are able to aid the body by providing the proteins necessary to support youthful, reproductive proteins. The body will happily take these and apply them to our cellular make-up. Thus, tripeptides are essential for any anti-aging product and more-so for lips, eyes, neck and other extraordinarily thin sections of our skin that subsequently show our age more quickly. Note: Most products containing tripeptides average at about $75.

The Trifecta: Orchid Extract, Algae Extract, and Yeast Extract

The literature has been exploding with data supporting the efficacy of botanical extracts for a wide range of functionalities including protection from photo aging, reducing inflammation, and providing antimicrobial activity.

Orchid Extract

Surprisingly, orchids have become an ideal ingredient for skin care products in addition to looking gorgeous in your entryway. Orchid leaves contain Orchicyanin I, Orchicyanin II and Cyanin, all of which belong to a group of plant pigments called Anthocyanins (not to be confused with cyanide).

These anthocyanins are part of the plant’s protective mechanism as anthocyanins are synthesized in response to environmental stressors such as UV radiation, temperature extremes, drought, disease and pollution. This results in a cumulative effect of fine line reduction, anti-oxidant, and humectant properties. This helps the human skin to restore and maintain a bright and radiant complexion.

Algae Extract

Mixed species and whole plant algae extract can be dissolved in a base of glycerin and water. You’ve likely seen this substance before under its other common names: Laminaria or Seaweed. Algae extract nourishes the skin & hair with vitamins and minerals and protects the skin from antioxidant stress. It also hydrates the skin.

Yeast Extract

Yeast extract is a strong humectant comprised of a complex mixture of proteins, sugars, and amino acids. The deliverance of these substances to the skin helps reduce the appearance of dark spots and hyperpigmentation by discouraging melanin production. More of the literature suggests results including: boosting collagen production and contributing to overall brightening of the skin. Yeast is also a great source of beta-glucans, which stimulates the immune system, and vitamin B.

Caprylic Capric Triglycerides

A mixture of triesters derived from coconut/palm oil and glycerin that is sometimes mistakenly referred to as fractionated coconut oil. Caprylic mainly works as an emollient (deeply penetrates skin and hair for lightweight moisturization), dispersing agent (in this context – enhances the delivery of vitamins and other nutrients), and solvent. Often used in anti-aging serums, these substances are excellent for their spreadability and smooth to-the-touch effect allowing for comfort and ease-of-wear.

Tribehenin (Glyceryl behenate)

In a nutshell: hydration and viscosity-increasing agent. There is research to support that Tribehenin is also an occlusive skin-conditioning agent. What this means is that the substance forms a protective barrier on the skin and reduces the process of water loss and helping to keep skin hydrated, plump, and soft.

Myristyl Myristate

100% natural vegetable derived ester utilizing only the Myristic fatty acids. While this website doesn’t necessary cite their references, I find time and time again their data to be backed by the literature. I love their overview of this substance and feel that it is very well-written. Check it out here! This may be a nice pocket reference for quick and on the go reviews of the ingredients on the ingredients that make-up your make-up. (:

Cetyl Esters, Ascorbyl Sodium Phosphate (a derivative of Vitamin C), Sodium PCA, Cetearyl Ethyl Hexanoate-Sorbitan-Isostearate Portulaca Pilosa Extract-Sucrose Cocoate-Palmitoyl, Benzoic Acid, Glycereth-2 Cocoate, Glucosamine HCL, Tocopheryl Acetate, Retinyl Palmitate, Synthetic Urea

This potent combination of various organic materials (mostly from the coconut – cue that song from Disney’s Moana) creates and seals your lips in a cocoon of naturally-derived humectants, cell growth promoters, amino acids, fatty acids, and anti-angiogenesis,  anti-inflammatory, and anti-degenerative nutrients. Many are biologics and are on the cutting edge of cosmetic technology with ample research to back their benefits and safety for topical (and in many cases even consumptive) use.

VEGAN WARNING! Be cautious in your research of cetyl esters. They were once harvested from whales but are now harvested from coconuts. Here’s a little more information on that whole process.

Butyrosperum Parkii (Shea Butter)

Highlighted in our post about LipSense’s patented gloss and the ingredients it is comprised of, this is one substance many are familiar with! Read more here.

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You can use a form of google known as “Google Scholars” to search research databases rather than searching through blog posts and other layman-curated information? Highly recommended if you decide you’d like to do your own research on just about any topic!

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  1. Sources of Hydroxy Fatty Acids https://naldc.nal.usda.gov/naldc/download.xhtml?id=IND93048066&content=PDF
  2. The Promise of the Castor Bean Archived March 9, 2016, at the Wayback Machine. by Elizabeth Johnson, Biodiesel Magazine, 2004-12-01.
  3. Thomas, Alfred (2005). “Fats and Fatty Oils”. Ullmann’s Encyclopedia of Industrial Chemistry. Weinheim: Wiley-VCH. doi:10.1002/14356007.a10_173.
  4. Beare-Rogers, J.; Dieffenbacher, A.; Holm, J.V. (2001). “Lexicon of lipid nutrition (IUPAC Technical Report)”. Pure and Applied Chemistry. 73 (4): 685–744. doi:10.1351/pac200173040685
  5. Rego Costa AC, Rosado EL, Soares-Mota M (2012). “Influence of the dietary intake of medium chain triglycerides on body composition, energy expenditure and satiety: a systematic review”. Nutr Hosp. 27 (1): 103–108. doi:10.1590/S0212-16112012000100011. PMID 22566308
  6. PubChem: Tribehenin https://pubchem.ncbi.nlm.nih.gov/compound/Tribehenin#section=Top
  7. Tripeptide Patent: https://www.google.com/patents/US6403112
  8. Antioxidative Properties of Tripeptide Libraries Prepared by the Combinatorial Chemistry. Koichiro Saito,†, Dong-Hao Jin,†, Tomohisa Ogawa,†, Koji Muramoto,*,†,‡, Eiko Hatakeyama,‡, Tadashi Yasuhara,§ and, and Kiyoshi Nokihara§,‖ Journal of Agricultural and Food Chemistry 2003 51 (12), 3668-3674. DOI: 10.1021/jf021191n
  9. “Yeast: The Surprisingly Beneficial New Skin Care Ingredient” (August 3, 2015). Yahoo, https://www.yahoo.com/beauty/yeast-the-surprisingly-beneficial-new-skin-care-125729261908.html.