seneplex titleThis amazing proprietary blend (trade secret) is in so many of our products because research has shown it works wonders in so many facets. This blog will cover a component by component analysis of the constituents that may be part of this revolutionary and highly effective complex.

β€œThe SenePlex Complex is an active kinetic enzyme containing a unique combination of ingredients, which when used properly, accelerates cellular renewal growth. SenePlex Complex impacts the growth of living cells and increases the cellular renewal process at a rate never before seen in the cosmetics and skincare industry, at an amazing 23.3% over an 8 week period.” –Research conducted for SeneGence International

The research is in! So what might be in this revolutionary formula that is helping cell turnover speed up and create that younger, healthful glow in your skin? Let’s take a look at each component that likely make up SenePlex!

Products that contain SenePlex Complex: Cleansers, Moisturizers, Eye Cream, Climate Control, Seneserum C, Collagen Night Pak, Nangai Oil, Under Eye Treatment, Exfoliator, Resurfacer, Acne Treatment, Foundations, Pearlizer, Concealer, BlushSense, ShadowSense, Silk Pore Minimizer, Anti Wrinkle Treatment, Translucid powders, Sunscreen, Tanning oil, Hand Cream, Parfums.

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Vitamin A

Vitamin A and various forms of retinoid are an important cell signaling pathway in many systems allowing for cell differentiation in mutiple layers of the skin. This vitamin can be absorbed by the skin to produce the cell signaling pathway to increase collagen production and activation of fibroblasts to increase firmness and elasticity. It is used synergystically with vitamin E for an overall increase in collagen production in the dermal layers.

Relevant reading:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC23340/
https://www.ncbi.nlm.nih.gov/pubmed/10692106

Vitamin_A_Skin_Science_Book

Vitamin C

Topical application of vitamin C has the propensity for accelerating the antiaging performance through increase of blood vessel formation (angiogenesis). The vascularization and movement of blood flow to an area starkly increases the cellular processes and availability for accelerated renewal.
Relevant reading:
https://bmcdermatol.biomedcentral.com/articles/10.1186/1471-5945-4-13

vitaminc

Vitamin E
Topical application of vitamin E acts as a fat soluble antioxidant in the damage of the epidermis through oxygen reaction and UV absorption . Specifically in the incidence of UV radiation, Vitamin E tocopherols act as cellular protection in the epidermis and are naturally ocurring in sebum, although topical application has immense antioxidant effects in protecting the photooxidation, it is the most effective at decreasing DNA damage and stability when combined with vitamin C. It is also used synergystically with Vitamin A to increase collagen production in the dermal layers of the skin, which increases firmness and elasticity.
Relevant reading:
http://www.tandfonline.com/doi/abs/10.1080/01635589109514160
http://www.tandfonline.com/doi/abs/10.1207/S15327914NC381_13
http://lpi.oregonstate.edu/mic/health-disease/skin-health/vitamin-E#reference65

Best-Benefits-Of-Vitamin-E-For-Skin

Orchid Extracts

Although peer reviewed research on these various extracts are sparse, many patent inventors assert they have found in their research that various forms of orchid extract assist in moisture content retention, hydration, keratinocyte regulation in the epidermis, and firmness, allowing an overall protective effect on the skin. The inhibition of mitochondrial protein signaling allows for longer cell longevity and slows the effects of aging on the dermal cells.
Relevant reading:
https://www.google.com/patents/US8293287
https://www.google.com/patents/US20120064021

orchid

Algae

Algae has recent attention of researchers for its moisture retention assistance, antioxidant properties, and possible application in skin depigmentation due to photo-oxidative damage. The anti-aging properties of this component will likely see more research in the coming years! It has shown promise in protecting the proteasome peptidase activity in keratinocytes when exposed to UVA and UVB radiation, showing it has potential in preserving the integrity of the epidermis when exposed to UV sources.
Relevant reading:
http://www.sciencedirect.com/science/article/pii/S0960852414017350
http://online.liebertpub.com/doi/abs/10.1089/ars.2006.8.136

algae

Phytoplankton Extract

A subset of marine algae, the concrete benefits of this additive are yet to be fully discovered, but some documentation has found phytoplankton has a positive impact on cell proliferation and renewal, increasing collagen and hyaluronic acid production depending on which species may be employed.
Relevant reading:
https://www.researchgate.net/profile/Jian_Qin/publication/286496916_Perspectives_on_marine_phytoplankton_as_sources_of_nutrition_and_bioenergy/links/566f492e08aec0bb67bf0e18.pdf
http://www.sciencedirect.com/science/article/pii/S0944711311005022

plankton

Seaweed

Seaweed extract is included as an anti-aging component, as it has been found to assist in increasing intercellular ATP exchange and increasing the oxygenation and moisture in tissues, firming the skin! It also has found effective application in wound care devices, emphasizing this formulation increases skin renewal and rejuvination while delivering minerals and components needed for epidermal and dermal processes.
Relevant reading:
https://www.google.com/patents/US20070003536
http://drs.nio.org/drs/handle/2264/489
https://link.springer.com/article/10.1007/s11101-011-9214-4
https://journals.co.za/content/mp_whsa/9/1/EJC190662

seaweed

Minerals

Minerals are needed for all cellular processes, so their presence is a given and may be derived from a combination of other sources or added for specific benefit such as to increase collagen synthesis and prevent collagen breakdown.
Relevant reading:
http://www.sciencedirect.com/science/article/pii/S0899900701006608.
http://onlinelibrary.wiley.com/doi/10.1046/j.1365-2133.2003.05540.x/full

keyboard-with-minerals

UGL Complex

Synthetically derived Urea

Hydroxyethyl urea is typically used as an emollient and binds water molecules regulating the moisture content of the skin in the stratum corneum or outermost layer of the epidermis consisting of the dead cells ready to be sloughed off. Urea is one of the components present with sebum that holds on to water molecules, this capacity decreases as we age, so topical application is an advantage to combat this lower urea level. It also increases skin permeability, allowing for the more effective delivery of other components in a skin care routine, making this crucial for multi-layer action of the SenePlex complex. It is also keratolytic, so it assists in the breakdown of dead skin cells on the outer most layer of the skin, helping new skin to be revealed.
Relevant reading:
http://thenakedchemist.com/what-is-urea-and-its-benefits-in-skincare/

hydroxyethylurea

Low Molecular Weight PolySaccharides
These are an important component as an antioxidant and reducing oxidative effects in the skin.
Relevant reading:
http://www.sciencedirect.com/science/article/pii/S0144861716311298
https://www.ncbi.nlm.nih.gov/pubmed/24706625
http://www.mdpi.com/1422-0067/14/10/19399/pdf

cell exterior

Glycosaminoglycans

This is a large classification of molecules including species of hyaluronan, chondroitin, and other molecules that have been found as an effective measure for the increase of collagen production, increase in skin elasticity (via elastin production stimulation) and firmness, and inhibit the activity of collagenase and elastase. The dermis and epidermis both contain glycosaminoglycans, so the regulatory activity of these molecules is crucial to skin health and renewal.

Relevant reading:
https://www.google.com/patents/US5804594
https://www.researchgate.net/profile/Juliane_Salbach-Hirsch/publication/51904093_Regenerative_potential_of_glycosaminoglycans_for_skin_and_bone/links/0912f501f7db623239000000.pdf
http://www.sciencedirect.com/science/article/pii/0009898186902421

glycosaminoglycans-structure

As an overall view in light of this scientifically formulated complex, let’s briefly review the layers of skin and cell renewal.

Collagen and Elastin are produced in the dermis, the amount changes as we age or as our cells age in response to dietary, external, and skin care factors. As collagen and elastin break down, skin becomes thinner, weaker, and loses firmness. Increasing this production as well as halting the action of collagenase and elastase while protecting your skin from UV radiation is key in reversing the signs of aging in skin. The top layer of the epidermis, the stratum corneum, gets sloughed off and with an increase in cell turnover and increase in collagen production, the protrusion of wrinkles through the epidermis and dermal layer is lessened as newer, healthier cells are revealed with this increase in turnover! Seneplex increases this rate by 23.3% in 8 weeks! Within 2 months, a change will be seen in all layers of the skin and the increase in collagen production will have your skin well on its way to looking and feeling younger and healthier!

normal-skinHistPaper01_Fig2OM dermishow-to-increase-collagenHeader-Collagen-Foods-For-Younger-Skindamaged_skinCollagen-Human-Molecule-1

Some Graphics previews to promote Our Revolutionary Seneplex (full versions available on Gumroad):

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