Let’s start up the debate once again! If you want to participate you must site a source of primary literature (peer-reviewed scientific article or text) to back your argument. We are looking only at clinical trials in human beings (no mammospheres, animal models, cultures, or in vitro studies) to keep our information as consistent, up-to-date, and accurate as possible. Aside from that! Join in on what I’m sure will be a hearty debate!Β 

Here we go!

The paraben used in our cosmetic (propylparaben) is used in extremely small quantities (less than 0.04%) and absorbs poorly into the skin when compared to just about any other alkane-substituted paraben (due to the increased size of its hydrocarbon substituent).


The paraben found in LipSense’s gloss formulation, at a concentration of less than 0.04% (w/w) of the components, is propylparaben. This is the n-propyl ester of para-hydroxybenzoic acid and is a naturally occurring substance found in many plants and a variety of insects.


This substance can be manufactured (as it is in our products) and is used in cosmetics, pharmaceuticals, and a number of foods as a preservative (increases shelf life and helps to prevent the growth of various microorganisms).

The substance is a white, fine crystalline powder that is odorless, tasteless, and not reported to be an irritant (although there are still people who can be allergic to this substance, an allergen and an irritant are often not mutually exclusive).


This substance is permitted by every world health authority and over 750 independent safety studies have reported similar results as to its safety over the period of just over a decade.

Both the final amended report on the safety assessment of parabens by the International Journal of Toxicology in 2008 and the CIR expert panel meeting in 2012, amongst hundreds of other national and international health authorities both funded by the cosmetic industry and not funded by the cosmetic industry, have found no direct correlation between parabens and cancer (or even mild levels of toxicology) to human cells.

There are a handful of studies that were done to cultures of mammalian cells with an overwhelming quantity of paraben exposure that signify the propagation of various enzymes and genes associated with cancer growth, however, these levels of exposure would be nearly impossible to achieve in the biochemistry of a living human being, and exposure to even an overwhelming quantity of water and/or oxygen can achieve similar results.

“Parabens occur naturally in some fruits such as blueberries and synthetic parabens have been used since the 1920s in food preservation. They are permitted by every world health authority and 500 independent safety studies have been carried out over the decades.” – UK Lush Fresh Cosmetics

“Parabens in cosmetic formulations applied to skin penetrate the stratum corneum in inverse relation to the ester chain length. Carboxylesterases hydrolyze parabens in the skin. Parabens do not accumulate in the body. Serum concentrations of parabens, even after intravenous administration, quickly decline and remain low. Acute toxicity studies in animals indicate that parabens are not significantly toxic by various routes of administration. Subchronic and chronic oral studies indicate that parabens are practically nontoxic. Numerous genotoxicity studies, including Ames testing, dominant lethal assay, host-mediated assay, and cytogenic assays, indicate that the Parabens are generally nonmutagenic, although Ethylparaben and Methylparaben did increase chromosomal aberrations in a Chinese Hamster ovary cell assay.” CIR Expert Panel 1

“The CIR Expert Panel considered exposures to cosmetic products containing a single parabens preservative (use level of 0.4%) separately from products containing multiple parabens (use level of 0.8%) and infant exposures separately from adult exposures in determining margins of safety (MOS). The MOS for infants ranged from approximately 6000 for single paraben products to approximately 3000 for multiple paraben products. The MOS for adults ranged from 1690 for single paraben products to 840 for multiple paraben products. The Expert Panel considers that these MOS determinations are conservative and likely represent an overestimate of the possibility of an adverse effect (e.g., use concentrations may be lower, penetration may be less) and support the safety of cosmetic products in which parabens preservatives are used.” – CIR Expert Panel 2

“In this study, we demonstrated that even in the presence of HRG, higher concentrations of parabens than those of E2 were needed to stimulate c-Myc expression and to cause proliferation of BT-474 cells. However, the PP and BP concentrations at which we observed estrogenic effects in the presence of HRG are within the range of concentrations previously reported in human breast tissue (Barr et al. 2012).” – Pan et al.

“FDA scientists continue to review published studies on the safety of parabens. At this time, we do not have information showing that parabens, as they are used in cosmetics, have an effect on human health.” – FDA

Time and time again, the NIH, FDA, CIR, NCBI, Medscape, the Journal of Toxicology and Applied Pharmacology, the International Journal of Toxicology, the Dermatology Review, and even Lush Cosmetics have found no danger in using, both topically and even injected directly into human tissue, no link to breast cancer, no measurable/significant changes in endocrine-related metabolism, and no accumulative effect in the body. This has been the case in 2007, 2008, 2012, 2013, 2016, and continuing into 2017. Over a decade of scientific studies, research, animal testing, reporting, and clinical trials and still NOTHING. So as far as science knows, this substance is 100% safe for daily consumption. Should you continue limiting your exposure? Sure! If you really feel compelled to do so please don’t let me talk you out of it. Science has been wrong before.

Published by Medline with the National Institute of Health in 2008, a Final amended report on the safety assessment of Methylparaben, Ethylparaben, Propylparaben, Isopropylparaben, Butylparaben, Isobutylparaben, and Benzylparaben as used in cosmetic products.
UK Lush Fresh Handmade Cosmetics and their take on Propylparabens labeled “the best paraben we can find – regardless of the price”.…/productsing…/ingredients/ucm128042.htm