*Author: Erin Hourihan, NFMSS Scientist

Hey beautiful! 🤓💋

We are so happy all of you are here.  It’s exciting to see this group growing every day!

I know its been quiet from the admins around here, but that’s not because we aren’t putting in work. 🏋🏋 Today I’ve seen old several old threads regarding R+F comparisons bumped to the top. Well, I have a surprise for you! 👇👇 February post from Exclusive Nerdy for my SeneSisters! 👇👇

🤓🤓 🎁🎁

🔑KEYWORDS: LashExtend, Lash boost, product comparison, ingredient breakdown

Q: How does SeneGence LashExtend compare to R+F Lash boost?

💰💰Lash Boost: $150/5ml ($30/ml)

💰LashExtend (brown): $55/3.7ml ($14.86/ml)

💰LashExtend (clear):$50/3.7ml ($13.51/ml)

For a complete ingredient breakdown of LashExtend read the Nerdy for My SeneSister review at https://nerdyformysenesisters.com/2017/04/02/1429/.

SeneGence claims a 25% increase in hair growth with one application daily, after only 2 weeks use.

R+F says for best results use Lash Boost for 8 weeks, but does not provide a % increase on their website.

Lash Boost: Water/Aqua/Eau, Butylene Glycol, Hydroxyethylcellulose, Keratin, Hydrolyzed Keratin, Biotin, Sodium Hyaluronate, Isopropyl Cloprostenate*, Octapeptide-2, Allantoin, Panthenol, Copper Tripeptide-1, Pantethine, Polypeptide-23, Cucurbita Pepo (Pumpkin) Seed Extract, Glycerin, Sea Water, Malus Domestica Fruit Cell Culture Extract, Hydrolyzed Glycosaminoglycans, Prunus Amygdalus Dulcis (Sweet Almond) Fruit Extract, Backhousia Citriodora Leaf Oil, Dipotassium Glycyrrhizate, Rhizobian Gum, Styrene/Acrylates/Ammonium Methacrylate Copolymer, Xanthan Gum, PVP, Lecithin, PEG-12 Dimethicone, Alcohol Denat., Chlorphenesin, Phenoxyethanol, Sorbic Acid, Sodium Hydroxide.

Water: solvent

Butylene Glycol: solvent & conditioning agent

Hydroxyethylcellulose: thickening agent

Keratin: a fibrous protein forming the main structural constituent of hair

Hydrolyzed Keratin: derived from sheep wool and other animal by-products. Revitalizes the hairs natural protective layer, rebuilds tensile strength, returns elasticity and reduces breakage. Has been shown to greatly reduce hair damage from harsh chemicals.

https://www.makingcosmetics.com/Keratin-Protein-Hydrolyzed_…

https://www.ncbi.nlm.nih.gov/m/pubmed/18412569/

http://www.cir-safety.org/…/de…/files/kerati092015slr%20.pdf

Biotin (Vit B7): hair-conditioning agent

https://www.ncbi.nlm.nih.gov/pubmed/11800048

Sodium Hyaluronate: naturally occurring polysaccharide found collagen and a variety of human tissues. It acts as a tissue lubricant.

*Isopropyl Cloprostenate (read update below): a synthetic prostaglandin- a class of drugs that bind to prostaglandin receptors. The FDA classifies prostaglandin analogues (PA) as drugs because they are known to alter the structure and function of the body. PA eye drops have been used since 1996 as a treatment for glaucoma. Glaucoma patients experienced side effects including unintended lengthening and darkening of the lashes, induced iris darkening, periocular skin pigmentation and dry eye. Pigmentation side effects are attributed to increased synthesis of melanin. When used for the purposes of lash lengthening this ingredient has come under scrutiny by the FDA for side effects including discoloration of the eye and area around the eye.

Update: This ingredient has resulted in a class action lawsuit with R&F. Read more here: https://www.cbsnews.com/news/rodan-fields-hit-with-suit-over-lash-boost-eyelash-enhancer/?ftag=CNM-00-10aac3a

http://prhsj.rcm.upr.edu/index…/…/article/viewFile/1543/1095

https://link.springer.com/…/10.2165/00002512-199914050-00006

https://www.truthinaging.com/…/eyelash-enhancers-eyed-by-fda

http://onlinelibrary.wiley.com/doi/10.1111/jocd.12281/full

http://www.cosmeticsandtoiletries.com/…/clai…/120476614.html

(Biological actives and peptides:)

Octapeptide-2: A peptide- so its involvement in some kind of cellular signaling. This particular peptide is not well defined in the literature. Additional research is needed on this ingredient.

http://www.kalidees.com/articles/Peptides_CnT_10_07.pdf (Although older, I loved how this article broke down peptides.)

https://pubchem.ncbi.nlm.nih.gov/compound/10102634

Allantoin: naturally occurring nitrogenous compound used as a skin conditioning agent. An over-the-counter medication used to treat or prevent dry skin.

http://www.ingredientstodiefor.com/item/Allantoin/56

http://citeseerx.ist.psu.edu/viewdoc/download…

Panthenol: a biologically active skin conditioner, help enhance hydration and healing

https://pdfs.semanticscholar.org/…/5e7b925f71483995027c89bf…

Copper Tripeptide-1: a peptide that has been reported to act in the signaling process for repair and regeneration

http://www.isclinical.com/…/WhitePaper_CopperTripeptide1_Ju…

Pantethine: long known, like 50 years, for its ability to nourish skin and hair.

https://patents.google.com/patent/US3285818A/en

https://www.ncbi.nlm.nih.gov/…/PM…/pdf/jbacter00607-0058.pdf

Polypeptide-23: a synthetic peptide. Additional research is needed.

(this came up, but I don’t think it’s relative https://www.sciencedirect.com/…/artic…/pii/S0022202X15343396)

Botanicals and other:
Cucurbita Pepo (Pumpkin) Seed Extract: rich in Vit A & C, zinc and beta-carotene, provides hydrating and antioxidant function.
https://www.skincarebyalana.com/…/wheretopurchasepumpkincle…

Glycerin: humectant

Sea Water: water rich in trace elements and minerals
https://www.oceaumarine.fr/en/assets/sea-water

Malus Domestica Fruit Cell Culture Extract: companies claim that apple extract has been shown to protect skin stem cells and delay senescence of hair follicles. Research does show skin effects including reduced water loss, improved water content and reduced levels of skin roughness.
https://mibellebiochemistry.com/…/phytocelltec-malus-domes…/
https://www.hindawi.com/journals/omcl/2015/709628/

Hydrolyzed Glycosaminoglycans: Glycosaminoglycans are highly polar and attract water, functioning as a humectant.

Prunus Amygdalus Dulcis (Sweet Almond) Fruit Extract: hair and skin conditioner

Backhousia Citriodora Leaf Oil: natural antimicrobial

Dipotassium Glycyrrhizate: humectant

Film formers, emulsifiers, viscosity increasing & suspending agents:

Rhizobian Gum, Styrene/Acrylates/Ammonium Methacrylate Copolymer,

Xanthan Gum, PVP (Polyvinylpyrrolidone), Lecithin, PEG-12 Dimethicone:

Denaturant & preservatives:
Alcohol Denat., Chlorphenesin, Phenoxyethanol, Sorbic Acid, Sodium Hydroxide.
https://www.fda.gov/Cosmetics/Labeling/Claims/ucm2005201.htm

Conclusions:
R+F Lash Boost uses a combination of moisturizing/conditioning ingredients, peptides and medications to increase lash growth. Primary lash growth enhancing ingredient is the PA, Isoprople Cloprostenate. In addition to documented side effects of PA in glaucoma patients, such as induced iris darkening, periocular skin pigmentation and dry eye, there is plenty of anecdotal evidence that its use as a lash serum results in unwanted side effects.

SeneGence LashExtend uses a combination or moisturizing/conditioning ingredients and peptides to promote lash growth, without medications.

Side effects resulting from the application of Lash Boost are do to some percentage of the product coming in contact with the eye. R+F website clearly states to avoid contact with the eye and if contact occurs to rinse with water. I don’t know about you, it seems unlikely that repeated application to the base of the eyelashes would not result in at least a small amount of product coming in contact with the eye. Gravity alone would cause residual product to fall into the eye.

R+F lash boost is approximately 2x the cost and extreme precaution should be used to prevent contact with the eye and unwanted side effects.

Another good source for reviews on lash growth serums:http://www.eyelash-growth.com/…/lash-boost-ingredients-bre…/

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